Elizabeth Ambrose

Introduction

Elizabeth Ambrose, Ph.D., is an associate professor in the College of Pharmacy at the University of Minnesota.  

The Ambrose laboratory’s research program focuses on CBRNE (chemical, biological, radiological, nuclear and high explosive) agent mitigation, particularly Bacillus anthracis (the causative agent of anthrax), the ricin toxin, and organophosphate nerve gases such as sarin, soman, and VX. Their goals include the design and optimization of small-molecule anthrax toxin lethal factor (LF) inhibitors, and ricin toxin A (RTA) inhibitors, to be used as emergency therapeutics in the event of bioterror attacks, and engineering enzyme active sites to rapidly and effectively hydrolyze fast-acting nerve agents.

Ambrose also has research and teaching interests in CNS-targeted drug design and optimization, focusing on psychiatric pharmacy and neuropharmacology.