Feature

From paws to possibilities

Researchers at the U of M have found success in a treatment for a fatal cancer in canines that could someday lead to a cure for similar cancers in humans.

Researchers at the University of Minnesota developed a way to diagnose hemangiosarcoma (HSA)—a fatal cancer in dogs—before a tumor has developed. Now, they’ve developed a treatment: A drug called eBAT that is resulting in improved survival rates for dogs diagnosed with HSA, when combined with early detection.

It’s an important discovery in its own right, but as it turns out, hemangiosarcoma is similar to angiosarcoma, a rare tumor that affects humans. In many dogs with HSA and humans with angiosarcoma, the tumors will have spread before diagnosis. The survival rate is extremely short, even with aggressive treatment. Only 50% of humans diagnosed with angiosarcoma will live longer than 16 months, and the prognosis for dogs with HSA is even worse: only about 10% will be alive one year after diagnosis.

It is among the most significant advancements in the treatment of canine HSA in decades. And it could be an important stepping stone in finding a cure for angiosarcoma and other cancers in humans.

As lead researcher Dr. Jaime Modiano says, “The ultimate goal for all of us is to create a world in which we no longer fear cancer.”

Meet the people behind the story

Dr. Jaime Modiano

Dr. Jaime Modiano

Professor, College of Veterinary Sciences, Masonic Cancer Center

Dr. Antonella Borgatti

Dr. Antonella Borgatti

Associate Professor, College of Veterinary Sciences, Masonic Cancer Center

Dr. David Largaespada

Dr. David Largaespada

Associate Director, Masonic Cancer Center

Linda Abel and Brinkley

Linda Abel and Brinkley

Participant, The Shine On Project

Thu, 02/13/2020 - 12:06
From paws to possibilities
https://twin-cities.umn.edu/news-events/driven/paws-possibilities
University of Minnesota, Twin Cities